2017-10-4 · dicating a possible interaction with a shared zinc–iron transporter, and Formigari et al. suggest that divalent metal transporter 1 (DMT1) is a possible candidate zinc–iron transporter. Though studies have shown that zinc treatment increases expression of DMT1 (4), it is unlikely to account for the decreased iron content in the
2006-3-6 · At least one member of the SLC39A family, IRT1 from Arabidopsis thaliana, is a metal transporter that can transport other trace elements, such as iron and manganese, in addition to zinc. The objective of this study was to analyze the capability of Zip14 to mediate non-transferrin-bound iron uptake by transiently transfecting HEK293H cells with ...
Abstract. The absorption of iron is influenced by numerous dietary and physiological factors. We have previously demonstrated that zinc treatment of intestinal cells increases iron absorption via induction of the apical membrane iron transporter divalent metal ion transporter-1 (DMT1). To better understand the mechanisms of zinc-induced iron absorption, we have studied the effect of zinc on ...
Moreover, intracellular concentrations of iron, copper, zinc, and manganese are higher than extracellular concentrations of these metals. For instance, intracellular concentrations of iron, copper, and zinc in E. coli are 100-fold, 1000-fold and 10,000 …
Background: Previous studies have identified the transmembrane protein ZIP8 (ZRT/IRT-like protein 8) as a zinc transporter.Results: ZIP8 can transport iron in addition to zinc and is up-regulated by iron loading nclusion: ZIP8 represents the third mammalian transmembrane iron import protein to be identified.Significance: ZIP8 may play a role in iron metabolism.
2014-8-15 · The intracellular iron transfer process is not well understood, and the identity of the iron transporter responsible for iron delivery to the secretory compartments remains elusive. In this study, we show Drosophila ZIP13 (Slc39a13), a presumed zinc importer, fulfills the iron effluxing role.
2021-10-6 · ZIP14 (slc39A14) is a zinc transporter induced in response to pro-inflammatory stimuli. ZIP14 induction accompanies the reduction in serum zinc (hypozincemia) of acute inflammation. ZIP14 can transport Zn(2+) and non-transferrin-bound Fe(2+) in vitro. Using a Zip14(-/-) mouse model we demonstrated that ZIP14 was essential for control of phosphatase PTP1B activity and phosphorylation …
2012-10-5 · Therefore, the principal physiologic substrates of ZIP8 and ZIP14 are likely to be iron and zinc, and to a lesser extent, manganese and cobalt. In conclusion, ZIP8 is a novel iron transporter whose expression profile suggests that it may play a role in iron metabolism in …
2020-3-13 · 2. Zinc Homeostasis and Its Role in Human Health. Zinc is the second most abundant micronutrient in the human body after iron [11,12].Based on bioinformatics research, approximately 2800 human proteins are presumed to bind zinc [], potentially requiring the divalent cation for catalytic, structural, and regulatory functions [5,13].Hereby, zinc is crucial for gene expression, is needed for the ...
Zinc (Zn) and iron (Fe) deficiency are widespread among citrus plants, but the molecular mechanisms regarding uptake and transport of these two essential metal ions in citrus are still unclear. In the present study, 12 members of the Zn/Fe-regulated transporter (ZRT/IRT)-related protein ( ZIP ) …
2001-10-9 · Competition for uptake between zinc and iron at the apical membrane of Caco-2 TC7 cells. Uptake of 1 μM 55 Fe 2+ was significantly inhibited (ANOVA and Scheffé''s post-hoc test, *P<0.001) by 100 μM unlabelled iron, but was unaffected by 100 μM zinc (a). In contrast, 1 μM 65 Zn 2+ uptake was significantly inhibited (ANOVA and Scheffé''s post-hoc test, *P<0.01) in the presence of both zinc ...
2021-8-18 · Interestingly, the uptake and transport of zinc and iron, another essential nutrient, is facilitated through a common group of proteins known as "zinc- …
2019-6-19 · Deficiency of zinc (Zn) and iron (Fe) is common in apple grown in orchards, which affects fruit yield and quality. However, the mechanisms of absorption and transport of Zn and Fe in apples are still unclear. In the present study, we aimed to identify MdZIP genes and explore the mechanism of response of MdZIPs to Zn and Fe deficiencies. Eighteen Zn- and Fe-regulated transporter-like protein ...
2021-11-10 · Identification of the key processes involved in the tumor progression, malignancy and the molecular factors which are responsible for the transition of the cirrhotic cells to the tumor cells, contribute to the detection of biomarkers for diagnosis of hepatocellular carcinoma (HCC) at an early stage. According to clinical data, HCC is mostly characterized by a significant decrease in zinc levels.
2019-1-14 · 2018), while expression of a wheat Vacuolar Iron Transporter (TaVIT2) using a similar promoter more than doubled the iron content of the white flour fraction (Connorton et al. 2017b ). This is illustrated in Fig. 2, which compares the contents of iron, zinc and phosphorus in bran and flour fractions of a TaVIT2 transgenic line with control ...
2009-10-7 · Zinc binds to the histidine-rich motif and the transmembrane domains form the zinc transport pore in both transporter types 38. Different isoforms have different affinities for zinc and also transport other transition metals such as cadmium, manganese, copper and iron, which may inhibit zinc transport.
2017-8-26 · controlled zinc and iron uptake and homeostasis network has been evolved in plants. The Zinc-regulated transporters, Iron-regulated transporter-like Proteins (ZIP) are capable of uptaking and transporting divalent metal ion and are suggested to play critical roles in balancing metal uptake and homeostasis, though a detailed analysis
2013-8-8 · The Zinc-regulated transporters, Iron-regulated transporter-like Proteins (ZIP) are capable of uptaking and transporting divalent metal ion and are suggested to play …
2015-7-1 · Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the whole body, tissue, cellular, and subcellular levels by a number of proteins, with zinc transporters being particularly important. In metazoan, two zinc transporter families, Zn transporters (ZnT) and Zrt ...
2014-3-26 · Second only to iron in trace-element abundance in the human body, and well known as a component of wound-healing salves, zinc has long been implicated in …
2017-7-28 · Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of many cellular proteins. Cellular zinc homeostasis involves the opposing action of two families of ...
2021-11-3 · Catsup is a zinc transporter functionally analogous to human ZIP7. There are at least ten putative ZIPs in the D. melanogaster genome [30–33].Among them, Catsup/CG10449 shares the highest overall homology with human ZIP7 (hZIP7, also known as SLC39A7, 52% identity and 64% similarity), which functions as a zinc transporter located on the ER/Golgi []. ...
2006-9-12 · Zip14 is a member of the SLC39A zinc transporter family, which is involved in zinc uptake by cells. Up-regulation of Zip14 by IL-6 appears to contribute to the hepatic zinc accumulation and hypozincemia of inflammation. At least three members of the SLC39A family transport other trace elements, such as iron and manganese, in addition to zinc. We analyzed the capability of Zip14 to …
2013-8-8 · Zinc (Zn) and iron (Fe) are essential micronutrients for plant growth and development, their deficiency or excess severely impaired physiological and biochemical reactions of plants. Therefore, a tightly controlled zinc and iron uptake and homeostasis network has been evolved in plants. The Zinc-regulated transporters, Iron-regulated transporter-like Proteins (ZIP) are capable of uptaking and ...
2019-6-4 · Introduction. Zinc (Zn) and iron (Fe) are essential micronutrients for all organisms, playing critical roles in various biological processes (Welch and Shuman 1995, Winterbourn 1995, Maret 2004).Zn availability in the soils of several agricultural areas is very low worldwide (Tiong et al. 2014) contrast, Fe availability in the soil is not limited, but it is difficult for plants to obtain Fe ...
In comparison to wild-type, the irt1 mutant responds to iron and zinc deprivation by altered expression of certain zinc and iron transporter genes, which results in the activation of ZIP1 in shoots, reduction of ZIP2 transcript levels in roots, and enhanced expression of IRT2 in roots.
2015-8-28 · Iron and zinc are important micronutrients for both the growth and nutrient availability of crop plants, and their absorption is tightly controlled by a metal uptake system. Zinc-regulated transporters, iron-regulated transporter-like proteins (ZIP), is considered an essential metal transporter for the acquisition of Fe and Zn in graminaceous plants. Several ZIPs have been identified in maize ...
2018-4-24 · Iron and Zinc Regulate Expression of a Putative ABC Metal Transporter in Corynebacterium diphtheriae. Eric D Peng Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
The zinc dietary intake is regulated in the intestine through several zinc transporters proteins (ZnT) and by iron-regulated transporter proteins (ZIP). Zinc bound to α2 -macroglobulin (a2m), albumin (alb) and other proteins and amino acid (AA) is distributed in the body. Zinc is prevalently stored in skeletal muscle, bone, liver and brain.
Background: Zinc (Zn) and iron (Fe) are essential micronutrients for plant growth and development, their deficiency or excess severely impaired physiological and biochemical reactions of plants. Therefore, a tightly controlled zinc and iron uptake and homeostasis network has been evolved in plants. The Zinc-regulated transporters, Iron-regulated transporter-like Proteins (ZIP) are capable of ...
2017-9-6 · Zinc transporter key to fighting pancreatic cancer and more. Date: September 6, 2017. Source: Michigan State University. Summary: Patients suffering from Alzheimer''s and Parkinson''s disease harbor ...
2001-10-26 · Direct interference, i.e. similar to that which could occur in the intestinal lumen, between zinc and iron was determined by measuring the uptake of 1 μM 55 Fe 2+ or 65 Zn 2+ in the presence or absence of 100 μM unlabelled metal. Radiolabelled iron uptake in the presence of an inwardly directed pH gradient was significantly inhibited by addition of a 100-fold excess of cold iron but was not ...
2021-1-1 · Zinc and iron contents in the leaves and roots of Arabidopsis Col-0 and atzne1 plants. (A–D) Twelve-day-old seedlings in were used for Zn and Fe contents measurements in the leaves and roots of Col-0, the atzne1 mutants, and complementation line atzne1-1/AtZNE1.1-GFP. Seedlings were grown on CK medium (1x), excess (5x), or depleted (0x) ionic ...
As zinc and iron can compete for transport into enterocytes 24,46, 47, there is a concern about providing zinc and iron supplements together and without food 24,48 . It is unlikely, however, that ...
Identification and characterization of the zinc-regulated ...